small t antigen การใช้

• Unlike for SV40, the MCV small T antigen directly transforms rodent cells in vitro.
• The prototype sequence of MCV has a 5387 base pair genome, and encodes characteristic polyomavirus genes including a large T antigen, small T antigen, VP1 and VP2 / 3 genes.
• Merkel cell polyomavirus small T antigen encodes a unique domain, called the LT-stabilization domain ( LSD ), that binds to and inhibits the FBXW7 E3 ligase regulating both cellular and viral oncoproteins.
• Polyomavirus small T antigens commonly target protein phosphatase 2A ( PP2A ), a key multisubunit regulator of multiple pathways including Akt, the mitogen-activated protein kinase ( MAPK ) pathway, and the stress-activated protein kinase ( SAPK ) pathway.